Current techniques for accomplishing this same series of procedures require extensive labor by skilled technicians and can take hours to several days to deliver results. The GeneXpert module forms the core of the Biohazard Detection System deployed nationwide by the United States Postal Service for anthrax testing in mail sorting facilities. An expanded menu of tests is currently in development.

The GeneXpert System is a 1 to 16-site, random access instrument integrating real-time amplification and detection features seen in the SmartCycler System, but delivering results from unprocessed samples in about an hour. The internal module is the common technology link between the SmartCycler and GeneXpert, performing real-time amplification and detection. The GeneXpert automates sample preparation, integrating the complex steps of DNA extraction in the microfluidic cartridges.

Each GeneXpert cartridge also incorporates a syringe drive, rotary drive and a sonic horn. The sonic horn delivers ultrasonic energy necessary to lyse the raw specimen and release nucleic acids contained within, while the combination of the syringe drive and rotary drive moves liquid between cartridge chambers in order to wash, purify and concentrate these nucleic acids. After the automated extraction is complete, the nucleic acid concentrate is moved into the cartridge reaction chamber where amplification and detection takes place. The GeneXpert software and barcode scanner easily manage data and display results. The GeneXpert has a small footprint and low power requirement making it suitable for applications requiring portability.